Bsj-4-116
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Bsj-4-116
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WebBiological Information. Research use only, not for human use. BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM.?It downregulates DDR genes through a premature termination of transcription, primarily through increasing poly (adenylation). BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC ... WebProduct name : BSJ-4-116 Catalog No. : HY-139039 CAS No. : 2519823-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, manufacture of substances. 1.3 Details of the supplier of the safety data sheet Company: MedChemExpress USA Tel: 609-228-6898 Fax: 609-228-5909
WebBSJ-4-116: BSJ-4-116 is a specific degrader of cyclin-dependent kinase 12 (CDK12). BSJ-4-116 exhibits potent antiproliferative effects. S9878 New: PF-07104091: PF-07104091 inhibits CDK2, which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation. S9880: MS140 WebJan 16, 2024 · BSJ-4-116 exhibits potent antiproliferative effects, alone and in combination with the poly(ADP-ribose) polymerase inhibitor Olaparib (HY-10162). Research Area： Cancer Targets： CDK PROTACs
WebBSJ-4-116 (10-10000 nM; 72 hours) exhibits potent antiproliferative effects in Kelly CDK12C1039F[1]. BSJ-4-116 (50 nM; 6-24 hours) decreases the level of CDK12 protein, regardless of the mutational status of the cell line [1] . WebChemsrc provides BSJ-4-116(CAS#:2519823-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of BSJ-4-116 are included as well.
WebBSJ-4-116 exhibited potent CDK12 degradation in Jurkat cells in a dose- and time-dependent manner, whereas CDK13 protein level was minimally affected Validation of …
WebModel: SPJ-716-14 Shown: Matte Bronze Material: Solid Brass or Copper Finish: Specify Electrical: 12V Engine: FB-TAB-6W Lumens: 300 Color Temp: 2700K Mounting: Direct … introductory bonusWebBiological Activity for BSJ-4-116. BSJ-4-116 is a selective CDK12 PROTAC ® Degrader. BSJ-4-116 selectively degrades CDK12 over a panel of other kinases and exhibits no … new oxford harvest dayWebManguera Dirección Hidráulica Honda Accord V6 3.0 1998/2002. 900 pesos$ 900. en. 12x. 91 pesos con 37 centavos $ 9137. Envío gratis. new oxford modern english book 5WebMoreover, BSJ-4-116 exhibited potent antiproliferative effects, alone and in combination with the poly(ADP-ribose) polymerase inhibitor olaparib, as well as when used as a single agent against cell lines resistant to covalent CDK12 inhibitors. Two point mutations in CDK12 were identified that confer resistance to BSJ-4-116, demonstrating a ... new oxford liuWebMoreover, BSJ-4-116 exhibited potent antiproliferative effects, alone and in combination with the poly(ADP-ribose) polymerase inhibitor olaparib, as well as when used as a single … introductory biomechanicsWebMoreover, BSJ-4-116 exhibited potent antiproliferative effects, alone and in combination with the poly(ADP-ribose) polymerase inhibitor olaparib, as well as when used as a single … new oxford modern english class 4 pdfhttp://product.autronicafire.com/products/fire-and-gas-detection-systems/fg-system-units/autrosafe-modules/bsj-310/ new oxford international school