Phosphatase of regenerating liver 3
Web WebFeb 10, 2024 · PRL-3, a cytokine-induced oncogenic phosphatase, is highly expressed in multiple myeloma cells and associated with poor outcome in this cancer. We studied whether PRL-3 influences metabolism. Cells transduced to express PRL-3 had higher aerobic glycolytic rate, oxidative phosphorylation, and ATP production than the control cells.
Phosphatase of regenerating liver 3
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WebPhosphatase of regenerating liver-3 (PRL-3) has received attention as a molecule associated with metastasis in various tumor types, including gastric cancer. However, its … Web OBJECTIVETo investigate the expression of phosphatase of regenerating liver-3 (PRL- 3) mRNA and evaluate its relationship with tumor invasion and metastasis in human colorectal carcinoma.
WebApr 6, 2011 · Phosphatase of regenerating liver-3 (PRL-3) has deserved attention as a crucial molecule in the multiple steps of metastasis. In the present study, we examined the mechanisms regulating PRL-3 expression, and assessed the clinical potential of PRL-3-targeted therapy in gastric cancer. PRL-3 genomic amplification was analyzed using … WebThe phosphatase of regenerating liver-3 (PRL-3) is important for IL-6-mediated survival of myeloma cells. Oncotarget. 2016;7(19):27295–27306. 17. Matsukawa Y, Semba S, Kato …
WebNov 30, 2024 · Phosphatase of regenerating liver (PRL-3) is a phosphatase found at high levels in several cancer types, where its expression is associated with survival. A recent PC cell line study has shown it to be involved in PC growth and migration. WebApr 10, 2024 · Background Phosphatase of regenerating liver-3 (PRL-3) is implicated in oncogenesis of hematological and solid cancers. PRL-3 expression increases metastatic …
WebLiver Regeneration. Liver regeneration after hepatectomy was assessed by the relative liver weight and hepatic DNA synthesis rate. At the time of hepatectomy, the relative liver weight (liver weight/body weight × 100) of the OJ-Hx group was significantly higher than that of the ED-Hx and ID-Hx groups (Fig. 2). In the ID-Hx group, the relative ...
WebThe phosphatase of regenerating liver-3 (PRL-3) is important for IL-6-mediated survival of myeloma cells. Oncotarget. 2016;7(19):27295–27306. 17. Matsukawa Y, Semba S, Kato H, Koma Y, Yanagihara K, Yokozaki H. Constitutive suppression of PRL-3 inhibits invasion and proliferation of gastric cancer cell in vitro and in vivo. critical thinking examples in the armyWebOct 26, 2024 · Phosphatase of regenerating liver (PRL) is a family of protein tyrosine phosphatases (PTPs) that are anchored to the plasma membrane by prenylation. They are frequently overexpressed in various types of malignant cancers and their roles in cancer progression have received considerable attention. critical thinking evan rowellWebPINION Phosphatases of regenerating liver are key regulators of metabolism in cancer cells – role of Serine/Glycine metabolism Pegah Abdollahia,b, ... Elsaadi S, et al. Phosphatase of regenerating liver-3 regulates cancer cell metabolism in multiple myeloma. FASEB J 2024; 35:e21344. PRL-3 promotes the serine/glycine pathway and induces ... critical thinking essay outlineWebPRL-3 promoted glucose uptake and lactate excretion, enhanced the levels of proteins regulating glycolysis and enzymes in the serine/glycine synthesis pathway, a side branch … critical thinking evaluation examplesWebMar 13, 2012 · Common features of the PRLs. Ever since phosphatase of regenerating liver (PRL)-3 was found to be overexpressed in liver metastatic tissue originating from colon cancer, but not in normal colon tissue nor in the primary tumour [], the PRL family of phosphatases has received much attention.There is strong evidence suggesting that not … buffalo illinois weatherWebNov 12, 2024 · Phosphatase of regenerating liver-3 ( PRL-3 ), which is also referred to as PTP4A3, is a member of the protein tyrosine phosphatase superfamily [ 11 ]. The protein … critical thinking exercise high schoolWebCirculating tumor cells (CTCs) and phosphatase of regenerating liver-3 (PRL-3) have been considered to be significant prognostic indicators in metastatic colorectal cancer (CRC). … critical thinking examples in social work